Multiple mammary tumours in a bitch: analysis of mitotic index, AgNOR count and c-erbB2 expression status: a case report

This case report of multiple mammary tumours in a Spitz bitch revealed the presence of three tumour masses, T-1, T-2 and T-3, of variable size, shape and texture on different mammary glands. Histopathological examination revealed these tumours to be of different histological type (T-1 – fibrosarcoma, T-2 – malignant mixed mammary tumour and T-3 – papillary adenocarcinoma). The mitotic index and AgNOR count was high in all three tumours indicative of a higher proliferation status of neoplastic cells while T-2 and T-3 showed overexpression of the c-erbB2 oncoprotein.